| MixTwice-package {MixTwice} | R Documentation |
Large-Scale Hypothesis Testing by Variance Mixing
Description
Implements large-scale hypothesis testing by variance mixing. It takes two statistics per testing unit – an estimated effect and its associated squared standard error – and fits a nonparametric, shape-constrained mixture separately on two latent parameters. It reports local false discovery rates (lfdr) and local false sign rates (lfsr). Manuscript describing algorithm of MixTwice: Zheng et al(2021) <doi: 10.1093/bioinformatics/btab162>.
Details
The DESCRIPTION file:
| Package: | MixTwice |
| Type: | Package |
| Title: | Large-Scale Hypothesis Testing by Variance Mixing |
| Version: | 2.0 |
| Imports: | alabama, ashr, fdrtool, Iso, stats |
| Date: | 2022-02-28 |
| Author: | Zihao Zheng and Michael A.Newton |
| Maintainer: | Zihao Zheng <zihao.zheng@wisc.edu> |
| Description: | Implements large-scale hypothesis testing by variance mixing. It takes two statistics per testing unit -- an estimated effect and its associated squared standard error -- and fits a nonparametric, shape-constrained mixture separately on two latent parameters. It reports local false discovery rates (lfdr) and local false sign rates (lfsr). Manuscript describing algorithm of MixTwice: Zheng et al(2021) <doi: 10.1093/bioinformatics/btab162>. |
| License: | GPL-2 |
Index of help topics:
MixTwice-package Large-Scale Hypothesis Testing by Variance
Mixing
mixtwice Large-scale hypothesis testing by variance
mixing
peptide_data Peptide array data example
Author(s)
Zihao Zheng and Michael A.Newton
Maintainer: Zihao Zheng <zihao.zheng@wisc.edu>
References
Zheng et al. MixTwice: Large scale hypothesis testing for peptide arrays by variance mixing. Bioinformatics, 2021.
Zheng et al. Disordered Antigens and Epitope Overlap Between Anti Citrullinated Protein Antibodies and Rheumatoid Factor in Rheumatoid Arthritis. Arthritis & Rheumatology 72.2 (2020): 262-272.
Examples
data(peptide_data)
## For more detail and example, use ?peptide_data and ?mixtwice