| Meta_Null_Model {MetaSKAT} | R Documentation |
Get parameters and residuals from H0
Description
Compute model parameters and residuals under the null model (H0) of no associations. It can be used only when individual level data are available.
Usage
Meta_Null_Model(y.list, x.list, n.cohort, out_type="C", n.Resampling=0)
Meta_Null_Model_EmmaX(y.list, x.list, n.cohort, K.list=NULL, Kin.File.list=NULL)
Arguments
y.list |
a list object for phenotypes. Each element should be a vector of phenotypes. If you have 3 cohorts, it should have 3 elements. |
x.list |
a list object for covariates. Each element should be a vector or a matrix of covariates. If there are 3 cohorts, it should have 3 elements. If there are no covariates to adjust for, the element should be "intercept". See the examples. |
n.cohort |
a numeric value of the number of cohort. |
out_type |
an indicator for the outcome type. "C" for continuous outcomes and "D" for dichotomous outcomes. |
n.Resampling |
internal use only. |
K.list |
a list object of the kinship matrices. If K.list=NULL, the function reads files in Kin.File.list to obtain kinship matrices. |
Kin.File.list |
a list object of emmax-kin output file names. |
Value
It returns an object that has model parameters and residuals. The returned object will be used to run MetaSKAT_wZ.
Author(s)
Seunggeun Lee
Examples
data(Example)
attach(Example)
#############################################################
# Compute a p-value of the first gene
obj<-Meta_Null_Model(y.list, x.list, n.cohort=3, out_type="D")
MetaSKAT_wZ(Z.list[[1]], obj)$p.value
#############################################################
# If you want to use the intercept-only model for the 2nd cohort
x.list[[2]]<-"intercept"
obj<-Meta_Null_Model(y.list, x.list, n.cohort=3, out_type="D")
MetaSKAT_wZ(Z.list[[1]], obj)$p.value