cubeClvR {MGDrivE}

Inheritance Cube: ClvR (Cleave and Rescue)

Description

Based on the Cleave-and-Rescue system of Oberhofer, this is a 2-locus Cas9-based toxin-antidote system. The first locus carries the Cas9, gRNAs, and a recoded copy of an essential gene. The second locus is the targeted essential gene. This gene can be completely haplosufficient (hSuf = 1) or completely haploinsufficient (hSuf = 0). It is assumed that having 2 copies of the gene (be it wild-type at the second locus or recoded at the first) confers complete viability.

Usage

cubeClvR(
  cF = 1,
  crF = 0,
  ccF = cF,
  ccrF = crF,
  cM = 1,
  crM = 0,
  ccM = cM,
  ccrM = crM,
  dW = 0,
  drW = 0,
  ddW = dW,
  ddrW = drW,
  hSuf = 1,
  eta = NULL,
  phi = NULL,
  omega = NULL,
  xiF = NULL,
  xiM = NULL,
  s = NULL
)

Arguments

cF

Female cutting rate, one ClvR allele

crF

Female functional resistance rate, one ClvR allele

ccF

Female cutting rate, two ClvR alleles

ccrF

Female functional resistance rate, two ClvR alleles

cM

Male cutting rate, one ClvR allele

crM

Male functional resistance rate, one ClvR allele

ccM

Male cutting rate, two ClvR alleles

ccrM

Male functional resistance rate, two ClvR alleles

dW

Female deposition cutting rate

drW

Female deposition functional resistance rate

ddW

Female deposition (HH) cutting rate

ddrW

Female deposition (HH) functional resistance rate

hSuf

Haplosufficiency level, default is completely sufficient

eta

Genotype-specific mating fitness

phi

Genotype-specific sex ratio at emergence

omega

Genotype-specific multiplicative modifier of adult mortality

xiF

Genotype-specific female pupatory success

xiM

Genotype-specific male pupatory success

s

Genotype-specific fractional reduction(increase) in fertility

Value

Named list containing the inheritance cube, transition matrix, genotypes, wild-type allele, and all genotype-specific parameters.