| sigEmax {MCPMod} | R Documentation |
Sigmoid Emax Model
Description
The model function for the sigmoid Emax model is defined as
f(d,\theta)=E_0+E_{max}\frac{d^h}{ED^h_{50}+d^h}
Usage
sigEmax(dose, e0, eMax, ed50, h)
Arguments
dose |
Dose variable |
e0 |
Placebo effect |
eMax |
Asymptotic maximum change from placebo effect |
ed50 |
Dose giving half of the asymptotic maximum effect |
h |
Hill parameter, determining the steepness of the model at the ED50 |
Details
The sigmoid Emax model is an extension of the (hyperbolic) Emax model by introducing an additional parameter h, that determines the steepness of the curve at the ed50 value. The sigmoid Emax model describes monotonic, sigmoid dose-response relationships.
Value
Response value
References
MacDougall, J. (2006). Analysis of dose-response studies - Emax model,in N. Ting (ed.), Dose Finding in Drug Development, Springer, New York, pp. 127–145
See Also
emax, logistic, betaMod,
linlog, linear, quadratic,
exponential