quadratic {MCPMod}

Quadratic model

Description

The model function for the quadratic model is defined as

f(d,\theta)=E_0+\beta_1d+\beta_2d^2

Usage

quadratic(dose, e0, b1, b2)

Arguments

dose

Dose variable

e0

Placebo effect

b1

beta1 parameter

b2

beta2 parameter (controls, whether model is convex or concave)

Details

This model is intended to capture a possible non-monotonic dose-response relationship.

Value

Response value

References

Pinheiro, J. C., Bretz, F. and Branson, M. (2006). Analysis of dose-response studies - modeling approaches, in N. Ting (ed.). Dose Finding in Drug Development, Springer, New York, pp. 146–171

See Also

logistic, sigEmax, linlog, linear, exponential, emax, betaMod