linlog {MCPMod}

Linear in log dose Model

Description

The model function for the linear in log model is defined as

f(d,\theta)=E_0+\delta \log(d + off)

where off is an offset parameter not estimated in the code.

Usage

linlog(dose, e0, delta, off = 1)

Arguments

dose

Dose variable

e0

Placebo effect

delta

Slope parameter

off

Offset value to avoid problems with dose=0 (treated as a fixed value in the code)

Details

The linear in log-dose model is intended to capture concave shapes. The parameter off is not estimated in the code but set to a pre-specified value.

Value

Response value

References

Pinheiro, J. C., Bretz, F. and Branson, M. (2006). Analysis of dose-response studies - modeling approaches, in N. Ting (ed.). Dose Finding in Drug Development, Springer, New York, pp. 146–171

See Also

logistic, sigEmax, linear, exponential, quadratic, emax, betaMod