osteopain {MBNMAdose}

Studies of treatments for pain relief in patients with osteoarthritis

Description

A dataset from a systematic review of interventions for pain relief in osteoarthritis, used previously in Pedder et al. (2019). The outcome is continuous, and aggregate data responses correspond to the mean WOMAC pain score at 2 weeks follow-up. The dataset includes 18 Randomised-Controlled Trials (RCTs), comparing 8 different agents with placebo. In total there were 26 different treatments (combination of dose and agent). The active treatments can also be grouped into 3 different classes, within which they have similar mechanisms of action.

Usage

osteopain

Format

A data frame in long format (one row per arm and study), with 74 rows and 7 variables:

• studyID Study identifiers

• agent Character data indicating the agent to which participants were randomised

• dose Numeric data indicating the standardised dose received

• class Character data indicating the drug class to which the agent belongs to

• y Numeric data indicating the mean pain score on the WOMAC scale in a study arm

• se Numeric data indicating the standard error for the mean pain score on the WOMAC scale in a study arm

• n Numeric data indicating the number of participants randomised

Source

Pfizer Ltd.

References

Pedder H, Dias S, Bennetts M, Boucher M, Welton NJ (2019). “Modelling time-course relationships with multiple treatments: Model-Based Network Meta-Analysis for continuous summary outcomes.” Res Synth Methods, 10(2), 267-286.