dnonparam {MBNMAdose}

Non-parameteric dose-response functions

Description

Used to fit monotonically increasing non-parametric dose-response relationship following the method of Owen et al. (2015))

Usage

dnonparam(direction = "increasing")

Arguments

direction

Can take either "increasing" or "decreasing" to indicate the monotonic direction of the dose-response relationship

Value

An object of class("dosefun")

References

Owen RK, Tincello DG, Keith RA (2015). “Network meta-analysis: development of a three-level hierarchical modeling approach incorporating dose-related constraints.” Value Health, 18(1), 116-26. ISSN 1524-4733 (Electronic) 1098-3015 (Linking), doi:10.1016/j.jval.2014.10.006, https://pubmed.ncbi.nlm.nih.gov/25595242/.

Examples

# Monotonically increasing dose-response
dnonparam(direction="increasing")

# Monotonically decreasing dose-response
dnonparam(direction="decreasing")