CUTOFF {MABOUST}

Returns the superiority or futility cutoff during a MABOUST trial.

Description

Returns the superiority or futility cutoff during a MABOUST trial.

Usage

CUTOFF(Delta, n, nTreat, nCat, gamma)

Arguments

Delta

Value of \Delta to test.

n

Current sample size in the trial.

nTreat

Number of active treatments in consideration, i.e. 1,...,K.

nCat

Number of ordinal outcome categories, i.e. J.

gamma

Length 3 vector of cutoff parameters.

Value

The set of active treatments to continue, an optimal treatment, or a set of equally optimal treatments. Also reports posterior mean utilities and ordinal outcome probabilities as well as pairwise comparisons of utility similarity, when appropriate.

References

[1] Chapple and Clement (2020), MABOUST: A Multi-Armed Bayesian Ordinal Outcome Utility-Based Sequential Trial. Submitted.

Examples

###Trial parameters
nCat = 6
nTreat = 3
Delta=5
n=300
###Design parameters
gamma= c(.5, .05, .05)
CUTOFF(Delta,n,nTreat,nCat,gamma)