| ACTG175 {LongCART} | R Documentation |
Converted AIDS Clinical Trials Group Study 175 (source: speff2trial package)
Description
ACTG 175 was a randomized clinical trial to compare monotherapy with zidovudine or didanosine with combination therapy with zidovudine and didanosine or zidovudine and zalcitabine in adults infected with the human immunodeficiency virus type I whose CD4 T cell counts were between 200 and 500 per cubic millimeter.
Usage
data(ACTG175)
Format
A data frame with 6417 observations from 2139 patients on the following 24 variables.
- pidnum
patient ID number
- age
age in years at baseline
- wtkg
weight in kg at baseline
- hemo
hemophilia (0=no, 1=yes)
- homo
homosexual activity (0=no, 1=yes)
- drugs
history of intravenous drug use (0=no, 1=yes)
- karnof
Karnofsky score (on a scale of 0-100)
- oprior
non-zidovudine antiretroviral therapy prior to initiation of study treatment (0=no, 1=yes)
- z30
zidovudine use in the 30 days prior to treatment initiation (0=no, 1=yes)
- zprior
zidovudine use prior to treatment initiation (0=no, 1=yes)
- preanti
number of days of previously received antiretroviral therapy
- race
race (0=white, 1=non-white)
- gender
gender (0=female, 1=male)
- str2
antiretroviral history (0=naive, 1=experienced)
- strat
antiretroviral history stratification (1:antiretroviral naive, 2:greater than 1 but less than 52 weeks of prior antiretroviral therapy, 3: greater than 52 weeks)
- symptom
symptomatic indicator (0=asymptomatic, 1=symptomatic)
- treat
treatment indicator (0=zidovudine only, 1=other therapies)
- offtrt
indicator of off-treatment before 96 weeks (0=no,1=yes)
- r
missing CD4 T cell count at 96 weeks (0=missing, 1=observed)
- cens
indicator of observing the event in days
- days
number of days until the first occurrence of: (i) a decline in CD4 T cell count of at least 50 (ii) an event indicating progression to AIDS, or (iii) death.
- arms
treatment arm (0=zidovudine, 1=zidovudine and didanosine, 2=zidovudine and zalcitabine, 3=didanosine)
- time
time in weeks
- cd4
CD4 T cell count
References
Hammer, S.M., et al. (1996), A trial comparing nucleoside monotherapy with combination therapy in HIV-infected adults with CD4 cell counts from 200 to 500 per cubic millimeter. New England Journal of Medicine, 335:1081-1090.