Generalized Spline Mixed Effect Models for Longitudinal Breath Data

---

Documentation for package ‘LoBrA’ version 1.0

• DESCRIPTION file.
• User guides, package vignettes and other documentation.

Help Pages

as.LOBdataset	Transformation of a single longitudinal data matrix into 'LoBrA' Data Object.
components	'LoBrA' Data Object (LDO) for Example data set
createBGComponents	Simulate background noise peaks
createBGData	Simulate background measurements
createExampleData	Create example data set for 'LoBrA'
createGoudermanData	Create the Gouderman Data Arrangement.
createInformativeComponents	Simulate informative peaks
GaudermanLDO	An S4 class to represent a 'Gouderman' LDO object, that was generated by the generalized gauderman algorithm.
GaudermanLDO-class	An S4 class to represent a 'Gouderman' LDO object, that was generated by the generalized gauderman algorithm.
GaudermanModelEvaluation	An S4 class to represent the result of the linear mixed effect modeling on a gauderman LDO.
GaudermanModelEvaluation-class	An S4 class to represent the result of the linear mixed effect modeling on a gauderman LDO.
getColor	Get colors for the plotting function.
getGeneralizedGaudermanDataFrame	Create Peak Matrices for Generalized 'Gauderman' linear mixed effect regression (LMER) Model with parameterized Times
getOptimalSpline	Extract the optimal spline model parameters from the ModelSelection Object.
getPvalue	Testing differences of groups with respect to a specific value and test.
LDO	An S4 class to represent a 'LoBrA' Data Object (LDO). It stores multiple time series data for muliple experiements and multiple Components. It allows repeated measurements of a component, irregular sampling, and unequal temporal spacing of the time points.
ldo	'LoBrA' Data Object (LDO) for Example data set
LDO-class	An S4 class to represent a 'LoBrA' Data Object (LDO). It stores multiple time series data for muliple experiements and multiple Components. It allows repeated measurements of a component, irregular sampling, and unequal temporal spacing of the time points.
LDOmodelselection	An S4 class to represent a model selection result based on an 'LDO'.
LDOmodelselection-class	An S4 class to represent a model selection result based on an 'LDO'.
LDOscreening	An S4 class to represent the screening of metabolites in an 'LDO'.
LDOscreening-class	An S4 class to represent the screening of metabolites in an 'LDO'.
LoBrA	LoBrA: A package for modeling longitudinal breath data
lobraModelSelection	Evaluation of different spline variants.
longDataExample	'LoBrA' Example Data Set
modelGoudermanLongitudinal	Fitting the Gouderman LME Model with using Gouderman-Data Arrangement.
plotGaudermanModel	Plotting helper function to plot a single generalized gouderman Model
plotGoudermanLongitudinalResults	Plotting the 'Gouderman' LME Model and Results.
plotLDOScreening	Plotting the screening results.
plotmodelSelectionEvaluation	Plotting results of Model Evaluation and Selection.
plotTimeSeries	Plotting function for a longitudinal data matrix (Internal Function)
powerSet	Creating the power set of a set.
screening	Screening of background or confounding components
selectComponents	Create a new 'LDO' Object that only contains the selected components.