LDAandLDAS-package {LDAandLDAS}

Linkage Disequilibrium of Ancestry (LDA) and LDA Score (LDAS)

Description

This is the software for Linkage disequilibrium of ancestry (LDA) and LDA score (LDAS) which is proposed by the papar Genetic risk for Multiple Sclerosis originated in Pastoralist Steppe populations, Barrie W, Yang Y, Attfield K E, et al (2022).

LDA quantifies the correlations between the ancestry of two SNPs, measuring the proportion of individuals who have experienced a recombination leading to a change in ancestry, relative to the genome-wide baseline.

LDA score is the total amount of genome in LDA with each SNP (measured in recombination map distance), which is useful for detecting the signal of “recombinant favouring selection”.

The codes for LDA and LDAS are hosted at https://github.com/YaolingYang/LDAandLDAscore.

Author(s)

Maintainer: Yaoling Yang [e-mail] (ORCID)

Authors:

• Daniel Lawson [e-mail] (ORCID)

References

Barrie, W., Yang, Y., Irving-Pease, E.K. et al. Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations. Nature 625, 321–328 (2024).