Bayesian Designs for Early Phase Clinical Trials


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Documentation for package ‘Keyboard’ version 0.1.3

Help Pages

decision.finding Return Dose Escalation or De-escalation Decision Given Number of Toxicity and Responses
example.kb Illustration of the Keyboard Design (Single-agent)
get.boundary.comb.kb Dose Escalation or De-escalation Boundaries for Drug-combination Trials
get.boundary.kb Dose Escalation or De-escalation Boundaries for Single-agent Trials
get.decision.obd.kb Boundary Table and Decision Matrix for Phase I/II Trials.
get.decision.obd2.kb Automatic Boundary and Decision Tables for Phase I/II Trials.
get.oc.comb.kb Operating Characteristics for Drug-combination Trials
get.oc.kb Operating Characteristics for Single-agent Trials
get.oc.obd.kb Generate Operating Characteristics to Find the Optimal Biological Dose
get.oc.obd2.kb Generate Operating Characteristics for OBD Finding Automaticallly
next.comb.kb Find the Next Dose Combination
plot_kb Plot Objects Generated by the Keyboard Design Package
select.mtd.comb.kb Maximum Tolerated Dose (MTD) Selection for Drug-combination Trials
select.mtd.kb Maximum Tolerated Dose (MTD) Selection for Single-agent Trials
select.obd.kb Select the Optimal Biological Dose (OBD) for Single-agent Phase I/II Trials
summary_kb Summarize Objects Generated by the Keyboard Design Package