ISOpureS1.model_optimize.mm.mm_deriv_loglikelihood {ISOpureR}

Compute the derivative of the loglikelihood relevant to mm for step 1

Description

Computes the derivative of the loglikelihood function relevant to optimizing the reference cancer profile, mm, for step 1

Usage

ISOpureS1.model_optimize.mm.mm_deriv_loglikelihood(ww, tumordata, model)

Arguments

ww

the mm_weights, with G entries

tumordata

a GxD matrix representing gene expression profiles of tumor samples

model

list containing all the parameters to be optimized

Value

The negative derivative the likelihood function relevant to optimizing mm. The derivative is taken not with respect to mm but with respect to unconstrained variables via a change of variables.

Author(s)

Gerald Quon, Catalina Anghel, Francis Nguyen