hybrid_MTD_selection {HybridDesign}

Select the maximum tolerated dose (MTD) for single-agent dose-finding studies

Description

Select the maximum tolerated dose (MTD) when the single-agent dose-finding study is completed

Usage

hybrid_MTD_selection(target, dose, npts, nDLT, elimdose)

Arguments

target

the target toxicity rate

dose

a vector containing the numerical dosage of each dose level

npts

a vector containing the number of patients treated at each dose level

nDLT

a vector containing the number of patients who experienced dose-limiting toxicity at each dose level

elimdose

the dosage at the dose level which is excluded due to excessive toxicity

Details

hybrid.MTD.selection() selects the MTD based on isotonic estimates of toxicity probabilities. The isotonic estimates are obtained by the pooled-adjacent-violators algorithm (PAVA) (Barlow, 1972 <doi: 10.1080/01621459.1972.10481216>).

Value

The selected dosage as MTD

Note

The dose levels above elim are all excluded for MTD selection.

Examples

hybrid_MTD_selection(target=0.3, dose=c(2,4,8,16,22,28,40), npts=c(2,4,8,16,22,28,40),
                     nDLT=c(0,0,0,0,1,0,2), elimdose=28)