hybrid {HybridDesign}

Implement Hybrid design with real data

Description

Obtain decision for the next dose level to be tested given current trial data.

Usage

hybrid(dose, nDLT, npts, currdose, nextdose=0, target, ncohort, cohortsize,
              eps1=0.05, eps2=0.05, a=1, b=1, cutoff.eli=0.95, tox.control=TRUE,
              cut.tox=0.8, esc.control=FALSE, cut.esc=0.5, regrule)

Arguments

dose

a vector containing the numerical dosage of each dose level

nDLT

a vector containing the number of patients who experienced dose-limiting toxicity at each dose level

npts

a vector containing the number of patients at each dose level

currdose

the dosage at the current dose level

nextdose

the dosage of next higher dose level; could be an intermediate dose

target

the target toxicity rate

ncohort

the total number of cohorts

cohortsize

the cohort size

eps1

modified Toxicity Probability Interval (mTPI) design parameter epsilon1. Default: 0.05

eps2

modified Toxicity Probability Interval (mTPI) design parameter epsilon2. Default: 0.05

a

Beta prior shape parameter 1. Default: 1

b

Beta prior shape parameter 2. Default: 1

cutoff.eli

Posterior probability cutoff of eliminating dose due to unacceptable toxicity. Default: 0.95

tox.control

indicator of whether to perform toxicity control. If TRUE, change "stay" to "deescalation" if the posterior probability of DLT rate greater than target+eps2 is greater than the toxicity control cutoff cut.tox

cut.tox

toxicity control cutoff. Default: 0.8

esc.control

indicator of whether to perform escalation control. If TRUE, change decision of "escalation" to "stay" if the posterior probability of DLT rate less than target-eps1 is greater than the escalation control cutoff cut.esc

cut.esc

escalation control cutoff. Default: 0.5

regrule

indicator of whether to apply additional overdose control rule

Value

This function returns the decision of implementing the Hybrid design with real trial data as a list, including: (1) dose transition boundaries of modified mTPI design, (2) decision table of modified mTPI design, (3) the decision given current data, (4) the summary table of tested dose levels

Examples

hybrid(dose=c(2,4,8,16,22,28,40), nDLT=c(0,0,0,0,1,0,2), npts=c(3,3,4,6,9,5,16), currdose=40,
       nextdose=54, target=0.3, ncohort=10, cohortsize=3, eps1=0.05, eps2=0.05, a=1, b=1,
       cutoff.eli=0.95, tox.control=TRUE, cut.tox=0.8, regrule=TRUE)