get_oc_hybrid {HybridDesign}

Generate operating characteristics for single-agent dose-finding studies using the Hybrid design

Description

Obtain the operating characteristics of the Hybrid design for single-agent dose-finding studies by simulation.

Usage

get_oc_hybrid(trueMTD, trueDLTvec, dose, target, ncohort, cohortsize,
                     eps1=0.05, eps2=0.05,a=1, b=1, cutoff.eli=0.95,
                     tox.control=TRUE, cut.tox=0.8, esc.control=FALSE, cut.esc=0.5,
                     ntrial, seednum=10000)

Arguments

trueMTD

the dosage of true maximum tolerated dose (MTD)

trueDLTvec

a vector of true dose-limiting toxicity (DLT) rates at each dose level

dose

a vector containing the numerical dosage of each dose level

target

target toxicity rate

ncohort

the total number of cohorts

cohortsize

the cohort size

eps1

mTPI design parameter epsilon1. Default: 0.05

eps2

mTPI design parameter epsilon2. Default: 0.05

a

Beta prior shape parameter 1. Default: 1

b

Beta prior shape parameter 2. Default: 1

cutoff.eli

Posterior probability cutoff of eliminating dose due to unacceptable toxicity. Default: 0.95

tox.control

indicator of whether to perform toxicity control. If TRUE, change "stay" to "deescalation" if the posterior probability of DLT rate greater than target+eps2 is greater than the toxicity control cutoff cut.tox

cut.tox

toxicity control cutoff. Default: 0.8

esc.control

indicator of whether to perform escalation control. If TRUE, change decision of "escalation" to "stay" if the posterior probability of DLT rate less than target-eps1 is greater than the escalation control cutoff cut.esc

cut.esc

escalation control cutoff. Default: 0.5

ntrial

the total number of trials to be simulated

seednum

the random seed for simulation

Value

This function returns the operating characteristics of the Hybrid design as a list, including: (1) Percentage of correct selection of the true MTD in all simulated trials, (2) Percentage of selecting a dose above MTD in all simulated trials, (3) Percentage of selecting a dose below MTD in all simulated trials, (4) Average number of patients treated at MTD in all simulated trials.

Examples

get_oc_hybrid(trueMTD=12, trueDLTvec=c(0.15,0.20,0.25,0.30,0.35), dose=c(3, 6, 12, 18, 24),
              target=0.25, ncohort=10, cohortsize=3, eps1=0.05, eps2=0.05, a=1, b=1,
              cutoff.eli=0.95, tox.control=TRUE, cut.tox=0.8, esc.control=FALSE, cut.esc=0.5,
              ntrial=100, seednum=10000)