get_boundary_mtpi {HybridDesign} | R Documentation |
Generate modified mTPI Design Decision Boundary
Description
Generate dose escalation and deescalation boundaries of modified Toxicity Probability Interval (mTPI) design with overdose control.
Usage
get_boundary_mtpi(
target,
ncohort,
cohortsize,
eps1 = 0.05,
eps2 = 0.05,
a = 1,
b = 1,
cutoff.eli = 0.95,
tox.control = FALSE,
cut.tox = 0.8,
esc.control = FALSE,
cut.esc = 0.5
)
Arguments
target |
target toxicity rate |
ncohort |
the total number of cohorts |
cohortsize |
the cohort size |
eps1 |
modified Toxicity Probability Interval (mTPI) design parameter epsilon1. Default: 0.05 |
eps2 |
modified Toxicity Probability Interval (mTPI) design parameter epsilon2. Default: 0.05 |
a |
Beta prior shape parameter 1. Default: 1 |
b |
Beta prior shape parameter 2. Default: 1 |
cutoff.eli |
Posterior probability cutoff of eliminating dose due to unacceptable toxicity. Default: 0.95 |
tox.control |
indicator of whether to perform toxicity control. If |
cut.tox |
toxicity control cutoff. Default: 0.8 |
esc.control |
indicator of whether to perform escalation control. If |
cut.esc |
escalation control cutoff. Default: 0.5 |
Value
This function returns the table of escalation and deescalation boundaries.
Examples
get_boundary_mtpi(target=0.30, ncohort=10, cohortsize=3)