get_boundary_mtpi {HybridDesign}R Documentation

Generate modified mTPI Design Decision Boundary

Description

Generate dose escalation and deescalation boundaries of modified Toxicity Probability Interval (mTPI) design with overdose control.

Usage

get_boundary_mtpi(
  target,
  ncohort,
  cohortsize,
  eps1 = 0.05,
  eps2 = 0.05,
  a = 1,
  b = 1,
  cutoff.eli = 0.95,
  tox.control = FALSE,
  cut.tox = 0.8,
  esc.control = FALSE,
  cut.esc = 0.5
)

Arguments

target

target toxicity rate

ncohort

the total number of cohorts

cohortsize

the cohort size

eps1

modified Toxicity Probability Interval (mTPI) design parameter epsilon1. Default: 0.05

eps2

modified Toxicity Probability Interval (mTPI) design parameter epsilon2. Default: 0.05

a

Beta prior shape parameter 1. Default: 1

b

Beta prior shape parameter 2. Default: 1

cutoff.eli

Posterior probability cutoff of eliminating dose due to unacceptable toxicity. Default: 0.95

tox.control

indicator of whether to perform toxicity control. If TRUE, change "stay" to "deescalation" if the posterior probability of DLT rate greater than target+eps2 is greater than the toxicity control cutoff cut.tox

cut.tox

toxicity control cutoff. Default: 0.8

esc.control

indicator of whether to perform escalation control. If TRUE, change decision of "escalation" to "stay" if the posterior probability of DLT rate less than target-eps1 is greater than the escalation control cutoff cut.esc

cut.esc

escalation control cutoff. Default: 0.5

Value

This function returns the table of escalation and deescalation boundaries.

Examples

get_boundary_mtpi(target=0.30, ncohort=10, cohortsize=3)


[Package HybridDesign version 1.0 Index]