CI_tp {HDXBoxeR}

Global confidence interval treshold from experimental standard deviation

Description

Calculation of global confidence interval using approach by for all protein states compared to first state in the data.frame. Reliable Identification of Significant Differences in Differential Hydrogen Exchange-Mass Spectrometry Measurements Using a Hybrid Significance Testing Approach Tyler S. Hageman and David D. Weis Analytical Chemistry 2019 91 (13), 8008-8016 DOI: 10.1021/acs.analchem.9b01325

Usage

CI_tp(df, replicates = 3, alpha = 0.01)

Arguments

df

standard deviation dataframe.

replicates

number of replicates. Default set to 3.

alpha

significance level. Set as default to 0.01

Value

treshold for determining significance.

Examples

file_nm<-system.file("extdata", "All_results_table.csv", package = "HDXBoxeR")
a<- output_tc(file_nm, seq_match=FALSE)
sd<-sd_timepoint(df=a, replicates=3)
CI_tp(df=sd, replicates=3, alpha=0.01 )
CI_tp(sd)