Group Sequential Design for Historical Control Trial with Survival Outcome


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Documentation for package ‘HCTDesign’ version 0.7.2

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EffDesign HCT design with interim monitoring for efficacy only
EffIM Monitoring the trial at interim looks for a trial with efficacy monitoring only
FutDesign HCT design with interim monitoring for futiity only
FutIM Monitoring the trial at interim looks for a trial with futility monitoring only
HCTSurvDesign HCT design with interim monitoring for both efficacy and futility
IM Monitoring the trial at interim looks for a trial with efficacy and futility boundaries
sf Log rank test for non-inferiority trial
SM Sample size in terms of number of subjects in the experimental group