dataHuman {FBFsearch}

Cell signalling pathway data

Description

Data on a set of flow cytometry experiments on signaling networks of human immune system cells. The dataset includes p=11 proteins and n=7466 samples.

Usage

data(HumanPw)

Format

dataHuman contains the following objects:

Obs

Matrix (7466x11) with the observations.

Perms

List of 5 matrices (1x11) each of which with a permutation of the nodes.

TDag

Matrix (11x11) with the adjacency matrix of the known regulatory network.

Source

Sachs, K., Perez, O., Pe'er, D., Lauffenburger, D., and Nolan, G. (2003). Casual protein- signaling networks derived from multiparameter single-cell data. Science 308, 504-6.

References

D. Altomare, G. Consonni and L. La Rocca (2012). Objective Bayesian search of Gaussian directed acyclic graphical models for ordered variables with non-local priors. Article submitted to Biometric Methodology.

Shojaie, A. and Michailidis, G. (2010). Penalized likelihood methods for estimation of sparse high-dimensional directed acyclic graphs. Biometrika 97, 519-538.