| pdlt {EWOC.Comb} | R Documentation |
Generating probability of DLT based on the EWOC2 model
Description
Generating probabiity of DLT based on the EWOC 2 drugs combination model
Usage
pdlt(rho00, rho01, rho10, eta, theta, x, y)
Arguments
rho00 |
a numeric value indicating the true value of the parameter rho00, the probability of DLT when the levels of drugs A and B are both 0 |
rho01 |
a numeric value indicating the true value of the parameter rho01, the probability of DLT when the levels of drugs A and B are 0 and 1, respectively |
rho10 |
a numeric value indicating the true value of the parameter rho10, the probability of DLT when the levels of drugs A and B are 1 and 0, respectively |
eta |
a numeric value indicating the true value of the eta, the interaction parameter |
theta |
a numerical value defining the proportion of expected patients to experience a medically unacceptable, dose-limiting toxicity (DLT) if administered the MTD |
x |
a numeric value of dose level for drug A |
y |
a numeric value of dose level for drug B |
Value
a numeric value indicating the probability of DLT with doses from input based on the logistic model
Examples
pdlt(rho00=0.01, rho01=0.2, rho10=0.9, eta=20, theta=0.2, x=0.2, y=0.3)