| mtdcurve {EWOC.Comb} | R Documentation |
Generating MTD curve based on logistic model for two drugs
Description
Generating MTD curve based on logistic model for two drugs
Usage
mtdcurve(rho00, rho01, rho10, eta, theta)
Arguments
rho00 |
a numeric value indicating the true value of the parameter rho00, the probability of DLT when the levels of drugs A and B are both 0 |
rho01 |
a numeric value indicating the true value of the parameter rho01, the probability of DLT when the levels of drugs A and B are 0 and 1, respectively |
rho10 |
a numeric value indicating the true value of the parameter rho10, the probability of DLT when the levels of drugs A and B are 1 and 0, respectively |
eta |
a numeric value indicating the true value of the eta, the interaction parameter |
theta |
a numerical value defining the proportion of expected patients to experience a medically unacceptable, dose-limiting toxicity (DLT) if administered the MTD |
Value
a plot showing the MTD curve based on the logistic model
Examples
mtdcurve(rho00=0.01, rho01=0.2, rho10=0.9, eta=20, theta=0.2)