EWOC.Comb-package {EWOC.Comb}

Escalation with Overdose Control using 2 Drug Combinations

Description

Implements Escalation With Overdose Control trial designs using two drug combinations described by this paper <doi:10.1002/sim.6961>(Tighiouart et al., 2016). It calculates the recommended dose for next cohorts and perform simulations to obtain operating characteristics.

Author(s)

Yujie Cui [aut, cre], Quanlin Li [aut], Mourad Tighiouart [aut]

Maintainer: Yujie Cui <[e-mail]>

References

Tighiouart M, Li Q and Rogatko A. A Bayesian adaptive design for estimating the maximuym tolerated dose curve using drug combinations in cancer phase I clinical trials. Statistics in Medicine. 2017, 36: 280-290.