po_pbibe {EQUIVNONINF} | R Documentation |

Implementation of the algorithm presented in *Par.* 10.3.3 of
Wellek S (2010) Testing statistical hypotheses of equivalence and
noninferiority. Second edition.

po_pbibe(n,eps,pio,zq,s,tol,sw,ihmax)

`n` |
sample size |

`eps` |
equivalence margin to an individual log-bioavailability ratio |

`pio` |
prespecified lower bound to the probability of obtaining an individual
log-bioavailability ratio falling in the equivalence range |

`zq` |
mean log-bioavailability ratio observed in the sample under analysis |

`s` |
square root of the sample variance of the log-bioavailability ratios |

`tol` |
maximum numerical error allowed for transforming the hypothesis of PBIBE into a region in the parameter space of the log-normal distribution assumed to underlie the given sample of individual bioavailability ratios |

`sw` |
step width used in the numerical procedure yielding results at a level of accuracy specified by the value chosen for tol |

`ihmax` |
maximum number of interval halving steps to be carried out in finding the region specified in the parameter space according to the criterion of PBIBE |

The program uses 96-point Gauss-Legendre quadrature.

`n` |
sample size |

`eps` |
equivalence margin to an individual log-bioavailability ratio |

`pio` |
prespecified lower bound to the probability of obtaining an individual
log-bioavailability ratio falling in the equivalence range |

`zq` |
mean log-bioavailability ratio observed in the sample under analysis |

`s` |
square root of the sample variance of the log-bioavailability ratios |

`tol` |
maximum numerical error allowed for transforming the hypothesis of PBIBE into a region in the parameter space of the log-normal distribution assumed to underlie the given sample of individual bioavailability ratios |

`sw` |
step width used in the numerical procedure yielding results at a level of accuracy specified by the value chosen for tol |

`ihmax` |
maximum number of interval halving steps to be carried out in finding the region specified in the parameter space according to the criterion of PBIBE |

`PO_PBIBE` |
posterior probability of the alternative hypothesis of PBIBE |

Stefan Wellek <stefan.wellek@zi-mannheim.de>

Peter Ziegler <peter.ziegler@zi-mannheim.de>

Wellek S: Bayesian construction of an improved parametric test for probability-based individual bioequivalence. Biometrical Journal 42 (2000), 1039-52.

Wellek S: Testing statistical hypotheses of equivalence and
noninferiority. Second edition. Boca Raton: Chapman & Hall/CRC Press, 2010, *Par.* 10.3.3.

po_pbibe(20,0.25,0.75,0.17451,0.04169, 10e-10,0.01,100)

[Package *EQUIVNONINF* version 1.0.2 Index]