powMCT {DoseFinding}

Calculate power for multiple contrast test

Description

Calculate power for a multiple contrast test for a set of specified alternatives.

Usage

powMCT(contMat, alpha = 0.025, altModels, n, sigma, S, placAdj=FALSE,
       alternative = c("one.sided", "two.sided"), df, critV,
       control = mvtnorm.control())

Arguments

contMat

Contrast matrix to use. The individual contrasts should be saved in the columns of the matrix

alpha

Significance level to use

altModels

An object of class ‘⁠Mods⁠’, defining the mean vectors under which the power should be calculated

n, sigma, S

Either a vector ‘⁠n⁠’ and ‘⁠sigma⁠’ or ‘⁠S⁠’ need to be specified. When ‘⁠n⁠’ and ‘⁠sigma⁠’ are specified it is assumed computations are made for a normal homoscedastic ANOVA model with group sample sizes given by ‘⁠n⁠’ and residual standard deviation ‘⁠sigma⁠’, i.e. the covariance matrix used for the estimates is thus sigma^2*diag(1/n) and the degrees of freedom are calculated as sum(n)-nrow(contMat). When a single number is specified for ‘⁠n⁠’ it is assumed this is the sample size per group and balanced allocations are used.

When ‘⁠S⁠’ is specified this will be used as covariance matrix for the estimates.

placAdj

Logical, if true, it is assumed that the standard deviation or variance matrix of the placebo-adjusted estimates are specified in ‘⁠sigma⁠’ or ‘⁠S⁠’, respectively. The contrast matrix has to be produced on placebo-adjusted scale, see optContr, so that the coefficients are no longer contrasts (i.e. do not sum to 0).

alternative

Character determining the alternative for the multiple contrast trend test.

df

Degrees of freedom to assume in case ‘⁠S⁠’ (a general covariance matrix) is specified. When ‘⁠n⁠’ and ‘⁠sigma⁠’ are specified the ones from the corresponding ANOVA model are calculated.

critV

Critical value, if equal to ‘⁠TRUE⁠’ the critical value will be calculated. Otherwise one can directly specify the critical value here.

control

A list specifying additional control parameters for the ‘⁠qmvt⁠’ and ‘⁠pmvt⁠’ calls in the code, see also ‘⁠mvtnorm.control⁠’ for details.

Value

Numeric containing the calculated power values

Author(s)

Bjoern Bornkamp

References

Pinheiro, J. C., Bornkamp, B., and Bretz, F. (2006). Design and analysis of dose finding studies combining multiple comparisons and modeling procedures, Journal of Biopharmaceutical Statistics, 16, 639–656

See Also

powN, sampSizeMCT, MCTtest, optContr, Mods

Examples

## look at power under some dose-response alternatives
## first the candidate models used for the contrasts
doses <- c(0,10,25,50,100,150)
## define models to use as alternative 
fmodels <- Mods(linear = NULL, emax = 25,
                logistic = c(50, 10.88111), exponential= 85,
                betaMod=rbind(c(0.33,2.31),c(1.39,1.39)),
                doses = doses, addArgs=list(scal = 200),
                placEff = 0, maxEff = 0.4)
## plot alternatives
plot(fmodels)
## power for to detect a trend
contMat <- optContr(fmodels, w = 1)
powMCT(contMat, altModels = fmodels, n = 50, alpha = 0.05, sigma = 1)

## Not run: 
## power under the Dunnett test
## contrast matrix for Dunnett test with informative names
contMatD <- rbind(-1, diag(5))
rownames(contMatD) <- doses
colnames(contMatD) <- paste("D", doses[-1], sep="")
powMCT(contMatD, altModels = fmodels, n = 50, alpha = 0.05, sigma = 1)

## now investigate power of the contrasts in contMat under "general" alternatives
altFmods <- Mods(linInt = rbind(c(0, 1, 1, 1, 1),
                                  c(0.5, 1, 1, 1, 0.5)),
                 doses=doses, placEff=0, maxEff=0.5)
plot(altFmods)
powMCT(contMat, altModels = altFmods, n = 50, alpha = 0.05, sigma = 1)

## now the first example but assume information only on the
## placebo-adjusted scale
## for balanced allocations and 50 patients with sigma = 1 one obtains
## the following covariance matrix
S <- 1^2/50*diag(6)
## now calculate variance of placebo adjusted estimates
CC <- cbind(-1,diag(5))
V <- (CC)%*%S%*%t(CC)
linMat <- optContr(fmodels, doses = c(10,25,50,100,150),
                   S = V, placAdj = TRUE)
powMCT(linMat, altModels = fmodels, placAdj=TRUE,
       alpha = 0.05, S = V, df=6*50-6) # match df with the df above

## End(Not run)