defBnds {DoseFinding} R Documentation

## Calculates default bounds for non-linear parameters in dose-response models

### Description

Calculates reasonable bounds for non-linear parameters for the built-in non-linear regression model based on the dose range under investigation.

For the logistic model the first row corresponds to the ED50 parameter and the second row to the delta parameter. For the sigmoid Emax model the first row corresponds to the ED50 parameter and the second row to the h parameter, while for the beta model first and second row correspond to the delta1 and delta2 parameters. See logistic, sigEmax and betaMod for details.

### Usage

   defBnds(mD, emax = c(0.001, 1.5)*mD,
exponential = c(0.1, 2)*mD,
logistic = matrix(c(0.001, 0.01, 1.5, 1/2)*mD, 2),
sigEmax = matrix(c(0.001*mD, 0.5, 1.5*mD, 10), 2),
betaMod = matrix(c(0.05,0.05,4,4), 2))


### Arguments

 mD Maximum dose in the study. emax, exponential, logistic, sigEmax, betaMod values for the nonlinear parameters for these model-functions

### Value

List containing bounds for the model parameters.

### Author(s)

Bjoern Bornkamp

fitMod
  defBnds(mD = 1)