amnesia {DiscreteDatasets}

Amnesia and other drug reactions in the MHRA pharmacovigilance spontaneous reporting system

Description

For each of 2,446 drugs in the MHRA database (column 1), the number of cases with amnesia as an adverse event (column 2), and the number of cases with other adverse event for this drug (column 3). In total, 684,652 adverse drug reactions were reported, among them 2,044 cases of amnesia.

Usage

data("amnesia")

data("amnesia_four_columns")

Format

amnesia is a data.frame with 2,446 rows representing drugs with the following two columns:

AmnesiaCases

Number of the amnesia cases reported for the drug.

OtherAdverseCases

Number of other adverse drug reactions reported for the drug.

Thus, each line describes a 2x2 table, e.g.:

1-ANDROSTENEDIOL	This drug	All other drugs
Amnesia cases	X_{i, 1}	2,044 - X_{i, 1}
Other adverse cases	X_{i, 2}	682,648 - X_{i, 2}

amnesia_four_columns is a data.frame with 2,446 rows representing drugs with the following four columns:

AmnesiaCases.ThisDrug

Number of the amnesia cases reported for the drug.

AmnesiaCases.AllOtherDrugs

Number of the amnesia cases reported for all other drugs.

OtherAdverseCases.ThisDrug

Number of other adverse drug reactions reported for the drug.

OtherAdverseCases.AllOtherDrugs

Number of other adverse drug reactions reported for all other drugs.

Thus, each line describes a 2x2 table:

1-ANDROSTENEDIOL	This drug	All other drugs
Amnesia cases	X_{i, 1}	X_{i, 3}
Other adverse cases	X_{i, 2}	X_{i, 4}

Details

The data was collected from the Drug Analysis Prints published by the Medicines and Healthcare products Regulatory Agency (MHRA), by Heller & Gur. See references for more details.

Note

The original amnesia dataset has been taken from the discreteMTP package, which is no longer available on CRAN. It has been reformatted such that the names in first column are now row descriptions; this way, the actual contents of the table are purely numeric.

Source

Drug Analysis Prints on MHRA site

References

R. Heller and H. Gur (2011). False discovery rate controlling procedures for discrete tests. arXiv pre-print arXiv:1112.4627v2 link.