ctpbw {DesignCTPB}

The clinical trial design for weak biomarker effect

Description

The dataset contains the 3-D rotable figure for the simulated nested two-subset design(weak biomarker effect), from which the optimal choice of each population's proportion and the optimal alpha split can be abtianed.

Format

The format is: List of 5 $ plot_power :plotly object $ plot_alpha :plotly object $ opt_r_split : numeric vector $ opt_power : numeric $ opt_alpha_split: numeric vector

plot_power

the 3-d rotatable plot of optimal power versus r2 and r3.

plot_alpha

the 3-d rotatable plot of optimal alpha versus r2 and r3

opt_r_split

The optimal cutoffs for the 3 dimensional clinical design

opt_power

The optimal power values corresponding to the optimal r split

opt_alpha_split

The optimal alpha split corresponding to the optimal r split