LDTestimate {DTR} R Documentation

## Function for calculating LTD estimates

### Description

The function computes the survival estimates and estimated standard errors for dynamic treatment regimes (DTRs) at the observed event times as proposed in Lunceford, Davidian and Tsiatis (2002) Equation (3) and Equation (10).

### Details

In sequentially randomized designs, there could be more than two therapies available at each stage. For simplicity, and to maintain similarity to the most common sequentially randomized clinical trials, a two-stage randomization design allowing two treatment options at each stage is used in the current version of the package. In detail, patients are initially randomized to either A1 or A2 at the first stage. Based on their response status, they are then randomized to either B1 or B2 at the second stage. Therefore, there are a total of four DTRs: A1B1, A1B2, A2B1, and A2B2.

### Value

The function returns an object of class DTR. See DTR.object for details.

### References

Lunceford JK, Davidian M, Tsiatis AA: Estimation of survival distributions of treatment policies in two-stage randomization designs in clinical trials. Biometrics 58:48-57, 2002

simLDTdata, DTR.object, print.DTR, summary.DTR, print.summary.DTR, plot.DTR
## Not run: