sesp.exactbinom {DTComPair} R Documentation

## Exact Binomial Test for Differences in Sensitivity and Specificity

### Description

Performs an exact binomial test for differences in sensitivity and specificity of two binary diagnostic tests in a paired study design.

### Usage

sesp.exactbinom(tab)


### Arguments

 tab An object of class tab.paired.

### Details

The function performs a standard exact binomial test.

An exact binomial test is recommended when the number of patients with differing results for test 1 and test 2 (discordant pairs) is small, i.e. <20 (Zhou et al., 2011).

### Value

A list containing:

 sensitivity A list containing test1 (sensitivity of test 1), test2 (specificity of test 2), diff (the difference in sensitivity, computed as test2 - test1) and the corresponding p.value. specificity A list containing test1 (specificity of test 1), test2 (specificity of test 2), diff (the difference in specificity, computed as test2 - test1) and the corresponding p.value. method The name of the method used to compare sensitivity and specificity, here “exactbinom”.

### References

Zhou, X., Obuchowski, N., and McClish, D. (2011). Statistical Methods in Diagnostic Medicine. Wiley Series in Probability and Statistics. John Wiley & Sons, Hoboken, New Jersey, 2nd edition.

sesp.mcnemar and tab.paired.

### Examples

data(Paired1) # Hypothetical study data
ftable(Paired1)
paired.layout <- tab.paired(d=d, y1=y1, y2=y2, data=Paired1)
paired.layout
exact.results <- sesp.exactbinom(paired.layout)
str(exact.results)
exact.results
exact.results\$sensitivity["p.value"]


[Package DTComPair version 1.0.3 Index]