| Arterial {CrossCarry} | R Documentation |
Arterial pressure data of crossover design
Description
Data of a crossover experiment with three treatments to control arterial pressure: treatment A is a placebo, treatments B and C are 20 and 40 mg doses of a test drug. Thus, there were six three-period sequences: ABC, ACB, BCA, BAC, CAB and CBA, each one of them was applied to two individuals lasting six weeks each. Due to ethical reasons, there was no washout period between the treatments. In each period, 10 consecutive measurements of diastolic arterial pressure were taken: 30 and 15 minutes before, and 15, 30, 45, 60, 75, 90, 120 and 240 minutes after the administration of the treatment
Usage
Arterial
Format
A data frame with 360 rows and 5 columns:
- Subject
The unique identifier of each of the patients
- Period
The period of application of each treatment
- Treatment
A is a placebo, treatments B and C are 20 and 40 mg doses of a test drug
- Pressure
diastolic arterial pressure
- Time
Measurement time
Source
Jones, B. and Kenward, M. G. (2015). Design and Analysis of Cross-Over Trials Third Edition. Chapman & Hall/CRC, Boca Raton