dehp {CorrBin}

R Documentation

Developmental toxicology study of DEHP in mice

Description

This data set is based on a National Toxicology Program study on diethylhexyl phthalate, DEHP. Pregnant CD-1 mice were randomly assigned to receive 0, 250, 500, 1000, or 1500 ppm of DEHP in their feed during gestational days 0-17. The uterine contents of the mice were examined for toxicity endpoints prior to normal delivery. The possible outcomes are 1) malformation, 2) death or resorption, 3) no adverse event.

Usage

dehp

Format

A 'CMData' object, that is a data frame with the following variables

Trt	factor giving treatment group
ClusterSize	the size of the litter
NResp.1	the number of fetuses with a type 1 outcome (malformation)
NResp.2	the number of fetuses with a type 2 outcome (death or resorption)
NResp.3	the number of fetuses with a type 3 outcome (normal)
Freq	the number of litters with the given ClusterSize/NResp.1-NResp.3 combination

Source

National Toxicology Program, NTP Study TER84064.

References

Tyl, R. W., Price, C. J., Marr, M. C., and Kimmel, C. A. (1988). Developmental toxicity evaluation of dietary di(2-ethylhexy)phthalate in Fischer 344 rats and CD-1 mice. Fundamental and Applied Toxicology 10, 395-412.

Examples

data(dehp)
library(lattice)
pl <- xyplot(NResp.1/ClusterSize + NResp.2/ClusterSize + NResp.3/ClusterSize ~ Trt, 
        data=dehp, outer=TRUE, type=c("p","a"), jitter.x=TRUE)
pl$condlevels[[1]] <- c("Malformed", "Dead", "Normal")
print(pl)

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