| dehp {CorrBin} | R Documentation |
Developmental toxicology study of DEHP in mice
Description
This data set is based on a National Toxicology Program study on diethylhexyl phthalate, DEHP. Pregnant CD-1 mice were randomly assigned to receive 0, 250, 500, 1000, or 1500 ppm of DEHP in their feed during gestational days 0-17. The uterine contents of the mice were examined for toxicity endpoints prior to normal delivery. The possible outcomes are 1) malformation, 2) death or resorption, 3) no adverse event.
Usage
data(dehp)Format
A 'CMData' object, that is a data frame with the following variables
| Trt | factor giving treatment group |
| ClusterSize | the size of the litter |
| NResp.1 | the number of fetuses with a type 1 outcome (malformation) |
| NResp.2 | the number of fetuses with a type 2 outcome (death or resorption) |
| NResp.3 | the number of fetuses with a type 3 outcome (normal) |
| Freq | the number of litters with the given ClusterSize/NResp.1-NResp.3 combination |
Source
National Toxicology Program, NTP Study TER84064.
References
Tyl, R. W., Price, C. J., Marr, M. C., and Kimmel, C. A. (1988). Developmental toxicity evaluation of dietary di(2-ethylhexy)phthalate in Fischer 344 rats and CD-1 mice. Fundamental and Applied Toxicology 10, 395-412.
Examples
data(dehp)
library(lattice)
pl <- xyplot(NResp.1/ClusterSize + NResp.2/ClusterSize + NResp.3/ClusterSize ~ Trt,
data=dehp, outer=TRUE, type=c("p","a"), jitter.x=TRUE)
pl$condlevels[[1]] <- c("Malformed", "Dead", "Normal")
print(pl)