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## The down syndrome data

### Description

Data on `N=11`

studies from the systematic review that examined the screening accuracy of shortened humerus and shortened femur of the fetus markers (two out of seven ultrasonographic markers or their combination in detecting Down syndrome in Smith-Bindman et al., 2001).

### Format

A data frame with 11 observations on the following 8 variables.

- down_n_00
the number of the test results in the diseased where the shortened humerus outcome is negative and the shortened femur outcome is negative

- down_n_01
the number of the test results in the diseased where the shortened humerus outcome is negative and the shortened femur outcome is positive

- down_n_10
the number of the test results in the diseased where the shortened humerus outcome is positive and the shortened femur outcome is negative

- down_n_11
the number of the test results in the diseased where the shortened humerus outcome is positive and the shortened femur outcome is positive

- nodown_n_00
the number of the test results in the non-diseased where the shortened humerus outcome is negative and the shortened femur outcome is negative

- nodown_n_01
the number of the test results in the non-diseased where the shortened humerus outcome is negative and the shortened femur outcome is positive

- nodown_n_10
the number of the test results in the non-diseased where the shortened humerus outcome is positive and the shortened femur outcome is negative

- nodown_n_11
the number of the test results in the non-diseased where the shortened humerus outcome is positive and the shortened femur outcome is positive

### References

Smith-Bindman R, Hosmer W, Feldstein V et al. Second-trimester ultrasound to detect fetuses with down syndrome: A meta-analysis (2001). *Journal of the American Medical Association*, **285**(8): 1044-1055.

*CopulaREMADA*version 1.6.2 Index]