sample.space.SM {CLAST} R Documentation

## Sample space enumeration

### Description

Creates all possible samples from a multi-stage group sequential trial for K>=2 by calling sample.space or sample.space.2.

### Usage

sample.space.SM(n,a,b)


### Arguments

 n Design vector of planned sample sizes a Design vector of lower futility boundaries b Design vector of upper superiority boundaries

### Value

list with components

 M number of trials for each possible trial outcome S number of responses for each possible trial outcome N number of patients for each possible trial outcome count combinatoric multiplier for probability distribution subcountM combinatoric components for probability distribution decision test decision for each possible trial outcome design list giving design vectors

Chris J. Lloyd

### References

Lloyd, C.J. (2020) Exact confidence limits after a group sequential single arm binary trial. Statistics in Medicine, Volume 38, 2389-2399. doi: 10.1002/sim.8909

### Examples

# Example 1 in table 1 of Lloyd (2020)
n=c(5,6,5,9)
a=c(2,4,5,12)
b=c(5,9,11,13)
sample.space.SM(n,a,b)
# Object describing all 26 possible outcomes for (s,m).


[Package CLAST version 1.0.1 Index]