fixcut_bin {BioPred}

Fixed Cutoff Analysis for Individual Biomarker Associated with Binary Outcome Variables

Description

This function conducts fixed cutoff analysis for individual biomarker associated with binary outcome variables.

Usage

fixcut_bin(
  yvar,
  xvar,
  dir,
  cutoffs,
  data,
  method = "Fisher",
  yvar.display = yvar,
  xvar.display = xvar,
  vert.x = FALSE
)

Arguments

yvar

Binary response variable name. 0 represents controls and 1 represents cases.

xvar

Biomarker name.

dir

Cutoff direction for the desired subgroup. Options are ">", ">=", "<", or "<=".

cutoffs

A vector of candidate cutoffs.

data

The dataset containing the variables.

method

Method for cutoff selection. Options are "Fisher", "Youden", "Conc.Prob", "Accuracy", or "Kappa". - "Fisher": Minimizes the Fisher test p-value. - "Youden": Maximizes the Youden index. - "Conc.Prob": Maximizes sensitivity * specificity. - "Accuracy": Maximizes accuracy. - "Kappa": Maximizes Kappa coefficient.

yvar.display

Display name of the response variable.

xvar.display

Display name of the predictor variable.

vert.x

Whether to display the cutoff in a 90-degree angle when plotting (saves space).

Value

A list containing statistical summaries, selected cutoff statistics, selected cutoff value, confusion matrix, and a ggplot object for visualization.