BHTSpack-package {BHTSpack}R Documentation

Bayesian Multi-Plate High-Throughput Screening of Compounds

Description

Can be used for joint identification of candidate hits from multiple assays, in drug discovery. This package implements the framework of I. D. Shterev, D. B. Dunson, C. Chan and G. D. Sempowski. "Bayesian Multi Plate High Throughput Screening of Compounds", arXiv:1709.10041, September 2017. This project was funded by the Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under contract No. HHSN272201400054C entitled "Adjuvant Discovery For Vaccines Against West Nile Virus and Influenza", awarded to Duke University and lead by Drs. Herman Staats and Soman Abraham.

Details

The DESCRIPTION file:

Package: BHTSpack
Type: Package
Title: Bayesian Multi-Plate High-Throughput Screening of Compounds
Version: 0.6
Authors@R: c(person(c("Ivo", "D."), "Shterev", role = c("aut", "cre"), email = "i.shterev@gmail.com"), person(c("David", "B."), "Dunson", role = "aut"), person("Cliburn", "Chan", role = "aut"), person(c("Gregory", "D."), "Sempowski", role = "aut"))
Description: Can be used for joint identification of candidate compound hits from multiple assays, in drug discovery. This package implements the framework of I. D. Shterev, D. B. Dunson, C. Chan and G. D. Sempowski. "Bayesian Multi-Plate High-Throughput Screening of Compounds", Scientific Reports 8(1):9551, 2018. This project was funded by the Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under contract No. HHSN272201400054C entitled "Adjuvant Discovery For Vaccines Against West Nile Virus and Influenza", awarded to Duke University and lead by Drs. Herman Staats and Soman Abraham.
Depends: R (>= 3.2.3), R2HTML (>= 2.3.2), xtable (>= 1.8-2)
VignetteBuilder: knitr
Suggests: knitr
License: GPL-3
LazyLoad: yes
Author: Ivo D. Shterev [aut, cre], David B. Dunson [aut], Cliburn Chan [aut], Gregory D. Sempowski [aut]
Maintainer: Ivo D. Shterev <i.shterev@gmail.com>

Index of help topics:

BHTSpack-package        Bayesian Multi-Plate High-Throughput Screening
                        of Compounds
abfun                   package internal function
alpha.u                 package internal function
b.u                     package internal function
bhts                    Bayesian High-Throughput Screening
bhts2HTML               Convert to HTML
data.create             Create Synthetic Data
fdr.r                   package internal function
h.pr.u                  package internal function
hatpai.u                package internal function
ind.u                   package internal function
lambda.u                package internal function
lg.mu.sig               package internal function
mu.k.u                  package internal function
nu.u                    package internal function
pai.u                   package internal function
ptrace                  Trace (ACF) Plots
r.fdr                   Significant Hits
sig.k.u                 package internal function
tau.u                   package internal function
z.pr.u                  package internal function

Author(s)

I. D. Shterev, D. B. Dunson, C. Chan and G. D. Sempowski

Maintainer: I. D. Shterev <i.shterev@duke.edu>

References

I. D. Shterev, D. B. Dunson, C. Chan and G. D. Sempowski. "Bayesian Multi-Plate High-Throughput Screening of Compounds". Scientific Reports, 8(1):9551, 2018.


[Package BHTSpack version 0.6 Index]