dat {BElikelihood}

Data example for bioequivalence (BE) study

Description

The dataset is a bioequivalence dataset from a fully repicated 2x4 crossover design with RTRT and TRTR as sequences. It is a subset of Example 4.4 in Chapter 4 of Patterson and Jones's book.

Usage

data(dat, package = 'BElikelihood')

Format

A data frame with 176 observations (from 44 subjects) on 6 variables:

subject

subject ID

sequence

RTRT or TRTR, where T and R stand for test and reference drugs, respectively

period

1 to 4 for crossover period

formula

T or R stand for test and reference drugs, respectively

AUC

a pharmacokinetic parameter - the area under the blood/plasma concentration-time curve

CMAX

a pharmacokinetic parameter - the peak concentration

Source

Patterson S and Jones B (2023). Bioequivalence and Statistics in Clinical Pharmacology. Chapman Hall/CRC Press.

Examples

data(dat)