BElikelihood-package {BElikelihood}

Likelihood method for analyzing bioequivalence (BE) trial data

Description

This package will calculate and plot the profile likelihoods for the mean difference and standard deviation ratios of a test drug to a reference drug for AUC or Cmax from various crossover designs commonly used in BE studies, such as a fully replicated crossover design (e.g., 2x4 two-sequence, four-period, RTRT/TRTR), a partially replicated crossover design (e.g., 2x3, two-sequence, three-period, RTR/TRT), and a two-sequence, two-period, crossover design design (2x2, RT/TR), where "R" stands for a reference drug and "T" stands for a test drug.

Author(s)

Maintainer: Liping Du [e-mail] (ORCID)

Authors:

• Leena Choi [e-mail] (ORCID)

• Cole Beck [e-mail] (ORCID)