LLL.SETTINGS {ASSISTant}

Design and trial settings used in the Lai, Lavori, Liao paper simulations

Description

A list of design and trial design settings used for analysis and simulations in the Lai, Lavori, Liao paper displayed in Tables 1 and 2. The elements of the list are the following

trialParameters

N

the sample size at each of three interim looks, the last being the final one; The length of this also determines the number of interim looks

type1Error

the overall type I error

eps

the fraction of type I error spent at each interim look

type2Error

the type II error desired

scenarios

A list of the 10 settings used in the simulations named S0, S1, ..., S10 as in the paper, each with three elements

mean

a 2\times J matrix of means, the first row for the null setting, the second for the alternative

sd

a 2\times J matrix of standard deviations, the first row for the null setting, the second for the alternative

prevalences

A list of two elements with prevalence vectors used in the paper; the lengths of these vectors implicitly define the number of groups.

table1

a vector of equal prevalences for six groups used in table 1

table2

a vector of prevalences used in table 2 of the paper

References

Adaptive Choice of Patient Subgroup for Comparing Two Treatments by Tze Leung Lai and Philip W. Lavori and Olivia Yueh-Wen Liao. Contemporary Clinical Trials, Vol. 39, No. 2, pp 191-200 (2014, doi:10.1016/j.cct.2014.09.001).