TwoGrpCopriEndpt.SimPower {ADCT} | R Documentation |
Power Simulation for Two Group Two Coprimary Endpoints Group Sequential Design.
Description
Given the group sequential design information, returns the simulated overall power.
Usage
TwoGrpCopriEndpt.SimPower(mu11,mu12, mu21, mu22, rho, tau,
alpha1, alpha2, alternative , Nmax, B)
Arguments
mu11 |
standardized mean value for coprimary endpoint 1 in group 1. |
mu12 |
standardized mean value for coprimary endpoint 2 in group 1. |
mu21 |
standardized mean value for coprimary endpoint 1 in group 2. |
mu22 |
standardized mean value for coprimary endpoint 2 in group 2. |
rho |
correlation coefficient between two coprimary endpoints. |
tau |
information time for the interim analysis. |
alpha1 |
significant level for the first stage. |
alpha2 |
significant level for the second stage. |
alternative |
indicates the alternative hypothesis and must be one of |
Nmax |
maximum sample size per group. |
B |
the simulation iterative time. |
Value
The evaluated power with attributes and computational error.
Author(s)
Yalin Zhu
References
Chang, M. (2014). Adaptive design theory and implementation using SAS and R. CRC Press.
Examples
# Example in Chang (2014) page 275
TwoGrpCopriEndpt.SimPower(mu11=0.2,mu12=0.25, mu21=0.005, mu22=0.015, rho=0.25,
tau=0.5, alpha1=0.0025, alpha2=0.024, alternative = "two.sided",Nmax=584, B=10000)